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Table 5 Fold-change in methacholine PC20 by treatment group at 8-months post-randomization among IPO13 variant carriers

From: Importin-13 genetic variation is associated with improved airway responsiveness in childhood asthma

  Budesonide (n = 214) Nedocromil/Placebo (n = 440)  
SNP Fold change (95% CI) p-value Fold change (95% CI) p-value Test for interaction
rs6671164 0.81 (0.38 – 1.68) 0.56 1.65 (1.05 – 2.61) 0.03 0.13
rs4448553 0.84 (0.40 – 1.77) 0.65 1.58 (1.00 – 2.51) 0.05 0.20
rs1990150 0.72 (0.31 – 1.69) 0.45 2.25 (1.35 – 3.74) 0.002 0.02
rs2240447 0.72 (0.34 – 1.53) 0.39 1.82 (1.14 – 2.89) 0.01 0.05
rs2486014 0.99 (0.37 – 2.62) 0.98 1.97 (1.10 – 3.53) 0.02 0.21
rs2301993 0.83 (0.39 – 1.79) 0.64 1.80 (1.13 – 2.86) 0.01 0.11
rs2301992 0.48 (0.15 – 1.52) 0.21 1.64 (0.78 – 3.47) 0.19 0.08
rs1636879 1.02 (0.38 – 2.74) 0.96 2.14 (1.20 – 3.83) 0.01 0.11
rs7412307 0.74 (0.34 – 1.60) 0.44 1.84 (1.14 – 2.96) 0.01 0.06
rs2428953 0.67 (0.26 – 1.70) 0.40 2.30 (1.32 – 4.00) 0.003 0.02
  1. Models adjusted for baseline log10-PC20, age, gender, height and clinic. Fold-change and confidence limits derived using beta-estimates derived from generalized linear models.