Figure 4

Cytokine/chemokine expression after lung IR. The expression of TNF-α, MIP-2 (CXCL2), RANTES (CCL5), and KC (CXCL1) in BAL fluid were significantly induced after IR in WT and A_2AAR KO mice (*p < 0.01 vs. WT Sham). Cytokine/chemokine induction was significantly impaired by ATL313 treatment in WT mice but not in A_2AAR KO mice (^#p < 0.001, WT IR+ATL313 vs. WT IR). WT Sham, WT lungs undergoing perfusion only; WT IR, WT lungs undergoing IR; KO IR, A_2AAR KO lungs undergoing IR; KO IR+ATL313, A_2AAR KO IR lungs treated with ATL313 (30 nM) during reperfusion.