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Table 2 Poly(I: C) induces the secretion of cytokines, chemokines, and growth factors into the airways.

From: Long-term activation of TLR3 by Poly(I:C) induces inflammation and impairs lung function in mice

 

Treatment

Protein (pg/ml)

PBS

100 μg Poly(I:C)

IFNγ

11.0 +/- 1.6

52.2 +/- 11.2 **

IL-1α

16.5 +/- 1.2

21.8 +/- 1.4 *

IL-6

8.8 +/- 1.5

879.0 +/- 171.2 **

CXCL10

30.3 +/- 5.9

411.3 +/- 34.9 **

JE

11.7 +/- 1.2

798.7 +/- 182.6 **

KC

6.2 +/- 1.3

55.4 +/- 6.5 **

GCSF

5.2 +/- 0.7

60.6 +/- 6.8 **

MIP1α

37.7 +/- 6.3

441.1 +/- 61.6 **

RANTES

0.5 +/- 0.04

155.8 +/- 41.6 **

TNFα

2.3 +/- 0.33

81.2 +/- 13.7 **

GMCSF

19.1 +/- 2.1

33.5 +/- 4.5 *

  1. Mice were administered PBS or 100 μg polyI:C (I.N.) every 24 h for three days. 24 h following the last polyI:C administration, BALs were performed. Analyte levels in BAL were determined. Data are expressed as mean pg/ml ± SEM from 6 – 8 mice. Statistical significance was determined using the Mann-Whitney test. * p < 0.05, **p < 0.01 when compared to PBS-treated mice. There was no measureable change in the following cytokines (data not shown): IL-1β, IL-2, IL-4, IL-5, IL-7, IL-10, IL-12(p70), IL-9, IL-13, IL-15, or IL-17.
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Respiratory Research

ISSN: 1465-993X

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