Figure 7

Sustained effect of 4B/4D and 7A AONs following once a week treatment and two weeks of smoke exposure. Mice were treated with endo-tracheal vehicle only (VEH), with combined 4B/4D and 7A AON (0.05, 0.1 or 0.2 mg/kg/day) or with control sequences (CTRL, 0.2 mg/kg/day) daily for one week, then once a week during the 2-week smoke exposure period, as per protocol design described in Figure 3B. Neutrophil counts (A), KC (B) and pro-MMP-9 levels (C) were measured in BAL. Results are expressed as percentage of neutrophils, KC or pro-MMP-9 levels in vehicle-treated and smoke-exposed animals (± SEM). *: p < 0.05; **: p < 0.01; ***: p < 0.001; t-test versus vehicle-treated without smoke exposure, versus vehicle-treated or versus CTRL, as indicated (n = 4 to 8 mice per group).