Table 1 Protease Inhibitors used in ex vivo collagen assay
From: N-α-PGP and PGP, potential biomarkers and therapeutic targets for COPD
Enzyme Inhibited | Chemical Composition( Source) | Efficacy | Ref. |
|---|---|---|---|
PE | Z-prolyl prolinal (Calbiochem) | Ki = 500 pM | [36] |
MMP-9 | C27H33N3O5S (Calbiochem) | IC50 = 5 nM | [37] |
MMP-1 | (4-(4-(Methanesulfonamido)phenoxy)phenylsulfonyl) methyloxirane (Calbiochem) | Ki = 45 μM | [38] |
HNE | N-(2-(4-(2,2-dimethylpropionyloxy)phenylsulfonylamino)benzoyl) aminoacetic acid N-(o-(p-pivaloyloxybenzene)sulfonylamino benzoyl)glycine (Calbiochem) | IC50 = 50 nM | [39] |