Figure 3
From: N-α-PGP and PGP, potential biomarkers and therapeutic targets for COPD
COPD sputum generates PGP de novo from collagen. Sputum from eight COPD patients and ten controls was incubated with Type I collagen for 24 hrs at 37°C. PGP in samples was measured using ESI-LC-MS/MS and expressed as amount of PGP generated (ng/ml) compared to sputum incubated with PBS. COPD sputum samples generated significantly greater amounts of PGP than control samples (* p < 0.05). Results are presented as mean ± SEM. Comparison between COPD and control sputum was performed using the two group t test.