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Table 1 Effect of in utero ASCFTR on lung parenchyma.

From: Adult onset lung disease following transient disruption of fetal stretch-induced differentiation

Age
(days)
Group % Parenchyma %
Airspace
A/P Lm
13 Control (eGFP) 0.18956612 0.712707 3.787066 18.8125
13 ASCFTR 0.24464738 0.673135 2.806436 20.99217
   p = .003 p = .03 p = .004 p = .012
60 Control (eGFP) 0.12055785 0.773347 6.508026 19.15
60 ASCFTR 0.12007576 0.778168 6.862095 20.2
   NS NS NS NS
90 Control (eGFP) 0.19871534 0.790174 4.622078 21.62444
90 ASCFTR 0.21126822 0.765983 4.568619 19.96945
   NS NS NS NS
120 Control (eGFP) 0.16403409 0.850143 5.70228 18.405
120 ASCFTR 0.16472577 0.880894 5.84488 18.14
   NS NS NS NS
210 Control (eGFP) 0.14146006 0.802755 6.003154 18.54375
210 ASCFTR 0.1651343 0.771823 4.979818 18.59688
   NS NS NS NS
  1. Detailed morphometric examination of the parenchyma at each age was performed by point counting at × 400 final magnification. Twenty images were examined from upper, middle and lower sections of each left lung following fixed-inflation. Volume densities of airspace wall, airspace and inter-airspace wall difference were determined by point counting. Inter-airspace wall difference (mean linear intercept (Lm)) was determined by counting the number of intercepts of a line of known length.