Table 1 Pulmonary hypertension rat models and pharmacologic treatment in the ten experimental groups
Group (Abbreviation) | Treatment |
|---|---|
Normal control (N) | Sham |
Normal+Simvastatin (NS) | Simvastatin on days 21~23 |
MCT (M) | MCT on day 1 |
MCT+Simvastatin (MS) | MCT on day 1; simvastatin on days 21~23 |
MCT+Simvastatin+SnPP (MSP) | MCT on day 1; co-treated with simvastatin and SnPP on days 21~23 |
MCT+SnPP (MP) | MCT on day 1; SnPP on days 21~23 |
Chronic Hypoxia (H) | Placed in a hypobaric chamber for 24 days |
Chronic Hypoxia+Simvastatin (HS) | Chronic hypoxia for 24 days, simvastatin on days 21~23 |
Chronic Hypoxia+Simvastatin+SnPP (HSP) | Chronic hypoxia for 24 days, co-treated with simvastatin and SnPP on days 21~23 |
Chronic Hypoxia+SnPP (HP) | Chronic hypoxia, SnPP on days 21~23 |