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Table 1 Dose metrics of the different experiments

From: Particles induce apical plasma membrane enlargement in epithelial lung cell line depending on particle surface area dose

Particle size

Particle number per well

Particle surface area [μm2 per well]

Particle volume [μm3 per well]

APM experiments

1 μm

3 × 107

1.1 × 108

1.9 × 107

1 μm

6 × 108

2.1 × 109

3.8 × 108

0.05 μm

3 × 107

1.6 × 105

1.1 × 103

0.05 μm

6 × 108

3.2 × 106

2.2 × 104

0.05 μm

4.5 × 1011

2.4 × 109

1.6 × 107

Constant particle number or surface area exposure

1 μm

1 × 107

3.5 × 107

6.3 × 106

1 μm

3 × 107

1.1 × 108

1.9 × 107

0.05 μm

3 × 107

1.6 × 105

1.1 × 103

0.05 μm

6.7 × 109

3.5 × 107

2.4 × 106

Concentration dependent particle entering

1 μm

1 × 107

3.5 × 107

6.3 × 106

1 μm

3 × 107

1.1 × 108

1.9 × 107

1 μm

6 × 107

2.1 × 108

3.8 × 107

1 μm

9 × 107

3.2 × 108

5.6 × 107

0.05 μm

3 × 107

1.6 × 105

1.1 × 103

0.05 μm

6 × 107

3.2 × 105

2.2 × 103

0.05 μm

6 × 108

3.2 × 106

2.2 × 104

0.05 μm

6 × 109

3.2 × 107

2.2 × 105

  1. Note: Particle dose per cell culture well was based on particle numbers. Corresponding particle surface area was calculated for spherical particles. All calculations are based on the effective diameters of 0.041 μm and 1.062 μm, respectively (see Material and Methods).
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Respiratory Research

ISSN: 1465-993X

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