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Table 2 Effect of Tiotropium treatment on levels of desmosine and Isodesmosine

From: The effect of tiotropium therapy on markers of elastin degradation in COPD

PATIENTS URINE
(ug/g creatinine)
PLASMA
(ng/ml)
SPUTUM
(ng/ml)
   FREE F/T(%)   
-1- 0 month
1 month
2 month
6.57
4.99
5.29
49.6
48.5
38.5
0.42
0.37
0.47
0.92
0.15
0.05
-2- 0 month
1 month
2 month
9.50
5.91
7.50
40.8
41.9
32.7
0.71
0.67
0.45
0.77
0.19
0.33
-3- 0 month
1 month
2 month
3.90
5.37
4.45
35.1
38.1
39.9
0.71
0.54
0.33
0.52
0.26
0.10
-4- 0 month
1 month
2 month
5.14
4.82
6.91
45.0
42.3
32.5
0.77
0.40
0.45
0.33
0.23
0.18
-5- 0 month
1 month
2 month
7.54
4.95
4.68
46.2
51.4
47.1
0.73
0.57
0.55
0.49
0.16
0.14
-6- 0 month
1 month
2 month
3.31
3.72
3.05
36.2
34.2
31.4
0.44
0.40
0.50
0.05
0.01
0.03
-7- 0 month
1 month
2 month
3.40
5.38
4.79
40.9
40.2
37.4
0.62
0.63
0.61
0.23
0.30
0.22
-8- 0 month
1 month
2 month
3.76
3.48
3.15
39.4
35.3
35.0
0.52
0.39
0.42
0.27
0.29
0.13
-9- 0 month
1 month
2 month
6.61
5.26
4.71
63.2
43.0
39.1
0.51
0.64
0.46
0.19
0.22
0.10
-10- 0 month
1 month
2 month
7.59
5.98
4.87
50.7
46.6
43.9
0.75
0.46
0.26
0.19
0.12
0.06
-11- 0 month
1 month
2 month
5.67
4.71
4.97
51.0
45.3
40.2
0.61
0.38
0.33
0.22
0.08
0.08
-12- 0 month
1 month
2 month
5.83
5.13
5.55
53.4
48.9
39.7
0.67
0.34
0.33
0.52
1.07
0.13
Normal Subjects[5]
(n-13)
2.52 (± 0.53) 19.0
(± 2.0)
0.19
(= + 0,01)
none