Table 2 Effect of Tiotropium treatment on levels of desmosine and Isodesmosine
From: The effect of tiotropium therapy on markers of elastin degradation in COPD
| PATIENTS |
URINE
(ug/g creatinine) |
PLASMA
(ng/ml) |
SPUTUM
(ng/ml) | ||
|---|---|---|---|---|---|
| FREE | F/T(%) | ||||
| -1- |
0 month 1 month 2 month |
6.57 4.99 5.29 |
49.6 48.5 38.5 |
0.42 0.37 0.47 |
0.92 0.15 0.05 |
| -2- |
0 month 1 month 2 month |
9.50 5.91 7.50 |
40.8 41.9 32.7 |
0.71 0.67 0.45 |
0.77 0.19 0.33 |
| -3- |
0 month 1 month 2 month |
3.90 5.37 4.45 |
35.1 38.1 39.9 |
0.71 0.54 0.33 |
0.52 0.26 0.10 |
| -4- |
0 month 1 month 2 month |
5.14 4.82 6.91 |
45.0 42.3 32.5 |
0.77 0.40 0.45 |
0.33 0.23 0.18 |
| -5- |
0 month 1 month 2 month |
7.54 4.95 4.68 |
46.2 51.4 47.1 |
0.73 0.57 0.55 |
0.49 0.16 0.14 |
| -6- |
0 month 1 month 2 month |
3.31 3.72 3.05 |
36.2 34.2 31.4 |
0.44 0.40 0.50 |
0.05 0.01 0.03 |
| -7- |
0 month 1 month 2 month |
3.40 5.38 4.79 |
40.9 40.2 37.4 |
0.62 0.63 0.61 |
0.23 0.30 0.22 |
| -8- |
0 month 1 month 2 month |
3.76 3.48 3.15 |
39.4 35.3 35.0 |
0.52 0.39 0.42 |
0.27 0.29 0.13 |
| -9- |
0 month 1 month 2 month |
6.61 5.26 4.71 |
63.2 43.0 39.1 |
0.51 0.64 0.46 |
0.19 0.22 0.10 |
| -10- |
0 month 1 month 2 month |
7.59 5.98 4.87 |
50.7 46.6 43.9 |
0.75 0.46 0.26 |
0.19 0.12 0.06 |
| -11- |
0 month 1 month 2 month |
5.67 4.71 4.97 |
51.0 45.3 40.2 |
0.61 0.38 0.33 |
0.22 0.08 0.08 |
| -12- |
0 month 1 month 2 month |
5.83 5.13 5.55 |
53.4 48.9 39.7 |
0.67 0.34 0.33 |
0.52 1.07 0.13 |
|
Normal Subjects[5]
(n-13) | 2.52 (± 0.53) |
19.0
(± 2.0) |
0.19
(= + 0,01) | none | |