Figure 3

Innate Cells in the Lungs. Naïve mice (day 0) had no statistically significant differences in the innate populations analyzed by flow cytometry (A); however, aged animals had the tendency to have a higher percentage of granulocytes. There was a delay in the kinetics of granulocyte and cDCs infiltration in the lungs of aged mice (white squares) (B and D), which suggested alterations in chemokine production. Lung macrophages did not show altered infiltration kinetics, but cleared more quickly from the lungs of adult mice (black circles) (C), which correlated with a quicker recovery from adult mice. Stars indicate statistical difference between aged and naïve animals.*P < 0.05. **P < 0.01. ***P < 0.001.