Upregulation of pirin expression by chronic cigarette smoking is associated with bronchial epithelial cell apoptosis

Table 1 Apoptosis-relevant Genes Up-regulated in the Airway Epithelium of Smokers¹

Gene ID	Description	Smokers/non-smokers (fold up)	p value	Reference relevant to apoptosis
Y07867	pirin	3.12	0.002	[21]
U77594	retinoic acid receptor responder 2	2.59	0.007	[39]
AB000584	prostate differentiation factor/growth differentiation factor 15	2.44	0.033	[40]
L27559	insulin-like growth factor binding protein 5	1.94	0.038	[41]
X51801	bone morphogenetic protein 7 (osteogenic protein 1)	1.83	0.046	[42]
M18728	carcinoembryonic antigen-related cell adhesion molecule 6	1.76	0.008	[43]
M38591	S100 calcium-binding protein A10	1.75	0.043	[44]

¹All up-regulated genes were evaluated for an association with apoptosis by reviewing published information about each gene available in public databases. Genes that had experimental evidence linking their expression to apoptosis were selected for further study.

ISSN: 1465-993X