Table 1 Correlations between the host gene expression and the genetically associated airway microbiome taxa and modules in COPD patients

Veillonella parvula

rs62442525

7

G

A

3.20E-06

NUDT1

1.11E-06

1.26E-04*

0.483

Veillonella parvula

rs62442525

7

G

A

3.20E-06

MAD1L1

7.59E-05

2.72E-03*

0.401

Stenotrophomonas maltophilia

rs9967912

20

A

C

4.00E-06

TTLL9

1.80E-04

3.08E-03*

0.402

Treponema denticola

rs6568956

6

A

C

5.46E-06

RWDD1

3.67E-04

7.76E-03*

0.371

Rothia mucilaginosa

rs79257400

1

C

G

1.90E-06

MAST2

1.52E-03

8.35E-03*

0.331

Prevotella intermedia

rs7204848

16

A

G

9.14E-07

BCAR1

1.17E-03

5.73E-02

0.335

Haemophilus influenzae

rs56396137

12

A

G

2.09E-06

LTA4H

6.76E-03

6.21E-02

0.304

Haemophilus influenzae

rs4352337

3

G

A

5.03E-06

KBTBD12

8.91E-03

7.20E-02

0.294

Campylobacter concisus

rs4683647

3

C

T

6.00E-06

ATP1B3

1.11E-02

7.84E-01

0.265

Neisseria mucosa

rs6557999

8

A

G

8.85E-06

PTK2B

1.99E-02

8.05E-01

−0.246

Streptococcus salivarius

rs6917641

6

A

G

9.54E-08

TBC1D32

3.57E-02

8.60E-01

0.228

Streptococcus pneumoniae

rs147224807

5

T

G

4.13E-06

AFF4

2.95E-02

8.89E-01

−0.242

Treponema denticola

rs6568956

6

A

C

5.46E-06

RSPH4A

3.91E-02

4.75E-01

0.220

Xanthomonas euvesicatoria

rs111818593

12

A

G

2.54E-06

MRPS35

3.13E-02

3.84E-01

−0.234

Ralstonia insidiosa

rs34568075

6

A

–

3.70E-06

TBC1D32

3.82E-02

9.14E-01

0.224

M00542: EHEC/EPEC pathogenicity signature

rs34823376

1

G

A

4.70E-06

ERRFI1

5.75E-03

2.03E-02*

−0.289

M00044: Tyrosine degradation

rs12311799

12

G

A

8.18E-06

KLHL42

5.17E-03

2.65E-02*

0.289

M00542: EHEC/EPEC pathogenicity signature

rs34823376

1

G

A

4.70E-06

PARK7

8.25E-03

3.14E-02*

−0.277

M00375: Hydroxypropionate-hydroxybutylate cycle

rs150193199

11

G

C

9.19E-06

NARS2

3.08E-03

4.67E-02*

−0.317

M00338: Cysteine biosynthesis

rs545977123

11

G

C

1.38E-06

EPS8L2

7.78E-03

5.54E-02

−0.28

M00332: Type III secretion system

rs34823376

1

G

A

6.20E-06

ERRFI1

3.14E-03

5.98E-02

−0.31

M00218: Fructose transport system

rs17121175

1

C

A

9.00E-06

NFIA

2.56E-02

9.02E-02

−0.234

M00332: Type III secretion system

rs34823376

1

G

A

6.20E-06

PARK7

6.98E-03

9.86E-02

−0.284

M00512: CckA-CtrA/CpdR (cell cycle control) two-component regulatory system

rs17824678

12

G

A

4.63E-06

MSRB3

2.30E-02

1.19E-01

0.244

P02010: ABC transporters

rs146351733

11

A

–

4.04E-06

PDGFD

4.00E-02

1.63E-01

−0.215

M00540: Benzoate degradation

rs1741618

20

T

A

4.35E-06

EEF1A2

4.33E-02

3.71E-01

−0.215

M00511: PleC-PleD (cell fate control) two-component regulatory system

rs5746415

22

A

G

2.86E-07

CECR2

2.78E-02

5.10E-01

−0.236