Fig. 2

Network analysis of biomarker taxa in patients with COPD. A, B Enriched and depleted taxa in patients with COPD identified by Linear discriminant analysis effect size (LEfSe) analysis in EndAECOPD (A) and SRP066375 cohort (B). Genera significantly enriched or depleted in COPD in both cohorts were noted with red or green, respectively. (C) Venn diagram and barplot showing overlapped genera with altered degree of negative interactions (percent change of > 5%) between COPD versus HC in EndAECOPD and SRP066375 cohort. Genera that were further recovered in data of Haldar et al. were noted with red. (D-G). Visualization of the Campylobacter and Haemophilus interactomes between COPD and HC in EndAECOPD (D, F) and SRP066375 cohort (E, G). # denotes paraphyletic group; • denotes unclassified genus; •• denotes classified but unnamed genus