Association and mediation between educational attainment and respiratory diseases: a Mendelian randomization study

Table 2 Mendelian randomization analysis of the effect of educational attainment on mediators

Exposure	Outcome	Method	N of SNPs	β	SE	P
EA	BMI	MR Egger	106	− 0.1879	0.1476	0.2059
		Weighted Median	106	− 0.1601	0.0283	1.5467e−8
		IVW	106	− 0.1604	0.0314	3.3414e−07
	Physical activity	MR Egger	263	0.1425	0.0740	5.5370e−02
		Weighted Median	263	0.2020	0.0244	1.2701e−16
		IVW	263	0.1953	0.0186	8.2055e−26
	Cigarettes per day	MR Egger	242	− 0.1910	0.1619	2.3935e−01
		Weighted Median	242	− 0.2816	0.0500	1.7228e−08
		IVW	242	− 0.3218	0.0414	7.2237e−15

EA educational attainment, BMI body mass index, IVW inverse variance weighted, MR Mendelian randomization

ISSN: 1465-993X