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Table 3 Univariable and multivariable Cox regression analysis for the composite outcome

From: Association between body fat decrease during the first year after diagnosis and the prognosis of idiopathic pulmonary fibrosis: CT-based body composition analysis

 

Univariable analysis

Multivariable analysis (model 1)

Multivariable analysis (model 2)

Multivariable analysis (model 3)

Variables

Hazard ratio

P value

Hazard ratio

P value

Hazard ratio

P value

Hazard ratio

P value

Age (year)

1.027 (1.006, 1.047)

0.009

1.051 (1.029, 1.074)

< 0.001

    

Sex (reference: female)

1.368 (0.921, 2.031)

0.120

1.805 (1.004, 3.244)

0.049

    

BMI (kg/m2)

0.955 (0.901, 1.013)

0.125

0.876 (0.823, 0.933)

< 0.001

0.871 (0.816, 0.929)

< 0.001

  

Change in BMI during the first year post-diagnosis (kg/m2)

0.922 (0.804, 1.058)

0.248

    

0.995 (0.863, 1.147)

0.941

Smoking history (reference: never smoker)

1.328 (0.932, 1.892)

0.117

1.203 (0.727, 1.988)

0.472

1.187 (0.818, 1.721)

0.367

  

Antifibrotics (reference: no use)

1.021 (0.703, 1.482)

0.914

      

Baseline GAP score

1.662 (1.418, 1.948)

< 0.001

  

1.570 (1.326, 1.858)

< 0.001

  

Baseline FVC (% predicted)

0.979 (0.968, 0.990)

< 0.001

0.986 (0.974, 0.998)

0.027

    

Baseline DLCO (% predicted)

0.978 (0.968, 0.987)

< 0.001

0.975 (0.963, 0.987)

< 0.001

    

FVC decline ≥ 5% during the first year post-diagnosis (% predicted) (reference: FVC decline < 5%)

2.244 (1.615, 3.118)

< 0.001

    

2.215 (1.582, 3.100)

< 0.001

DLCO decline ≥ 10% during the first year post-diagnosis (% predicted) (reference: DLCO decline < 10%)

2.261 (1.577, 3.241)

< 0.001

    

2.278 (1.584, 3.274)

< 0.001

Baseline pulmonary artery diameter (mm)

1.080 (1.037, 1.125)

< 0.001

1.082 (1.033, 1.133)

0.001

1.090 (1.039, 1.144)

< 0.001

  

IPF extent on baseline CT (%)

1.023 (1.011, 1.034)

< 0.001

1.007 (0.992, 1.023)

0.359

1.018 (1.004, 1.032)

0.009

  

Muscle area at T12-L1 on baseline CT (cm2) (reference: upper three quartiles)

1.092 (0.751, 1.588)

0.642

      

Change in muscle area at T12-L1 during the first year post-diagnosis (cm2) (reference: upper three quartiles)*

1.237 (0.854, 1.792)

0.261

      

Fat area at T12-L1 on baseline CT (cm2) (reference: upper three quartiles)

0.998 (0.685, 1.454)

0.992

      

Change in the fat area at T12-L1 during the first year post-diagnosis (cm2) (reference: upper three quartiles)*

1.619 (1.136, 2.307)

0.008

1.566 (1.066, 2.300)

0.022

1.503 (1.026, 2.202)

0.036

1.495 (1.039, 2.151)

0.030

  1. BMI: body mass index; GAP: gender, age, and physiologic variables; FVC: forced vital capacity; DLCO: diffusing capacity of carbon monoxide; IPF: idiopathic pulmonary fibrosis
  2. Model 1 is with baseline clinical-radiological variables; Model 2 is with baseline clinical-radiological variables including GAP score; Model 3 is with variables obtained at 1-year follow-ups
  3. The composite outcome was the occurrence of death or lung transplantation
  4. Multivariable Cox proportional hazard regression analysis was performed with variables that had P-values < 0.2 in the univariable analysis and BMI change since this factor was reported as a poor prognostic factor in prior study
  5. * The lowest quartile is a group with the highest reduction of fat or mass area
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Respiratory Research

ISSN: 1465-993X

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