Respiratory Research

Table 2 Multivariate analysis of factors influencing MMP-9 blood levels at Y1 and Y2

From: Blood MMP-9 measured at 2 years after lung transplantation as a prognostic biomarker of chronic lung allograft dysfunction

Predictors	Y1 analysis			Y2 analysis
Predictors	MMP-9 estimates	CI	p	MMP-9 estimates	CI	p
CLAD (vs Stable)	123.32	− 34–281	0.1	150.9	20–281	0.02
Cystic Fibrosis	1.08	− 193–195	1	− 112.51	− 254–29	0.1
ILD	− 39.11	− 247–169	0.7	21.73	− 149–192	0.8
Other	− 18.32	− 301–264	0.9	− 186.44	− 481–108	0.2
CMV mismatch	− 56.47	− 260–147	0.6	− 36.83	− 191–117	0.6
Fungal colo. pre Tx	− 12.69	− 163–138	0.9	129.13	1.7–257	0.05
Graft cold ischemia	− 0.51	− 1.3–0.3	0.2	− 0.46	− 1.2–0.3	0.2
Donor PaO2/FiO2	− 0.53	− 1.2–0.2	0.1	0.2	− 0.4–0.8	0.5
Induction treatment	− 61.32	− 241–118	0.5	− 108.01	− 260–44	0.1
ACR (> 1)	− 98.6	− 257–60	0.2	40.23	− 92–173	0.5
Bacterial infection (> 1)	− 6.23	− 197–184	0.9	97.94	− 59–255	0.2
Fungal infection (> 1)	147.54	− 10–305	0.07	− 28.73	− 156–98	0.6
Viral infection (> 1)	46.46	− 106–199	0.5	− 60.8	− 187–66	0.3

CLAD: chronic lung allograft dysfunction. ILD: interstitial lung disease. Other: other underlying diagnosis (pulmonary hypertension, sarcoidosis, connective tissue disease, bronchiectasis). The reference chose for underlying disease was COPD/emphysema. CMV: cytomegalovirus, mismatch referring to a transplantation with a recipient with negative serology and a donor with positive serology to CMV. ACR: acute cellular rejection, one or more episode within the first year post transplantation. The infection factors refers to bacterial, fungal or viral infection of the lower respiratory tract, one or more episode within the first year post transplantation

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