Fig. 4

Blood MMP-9 value at Y2. A Comparison of the MMP-9 plasmatic concentration at Y2 between recipients who then developed CLAD and those who remained stable in the next 2 years (p = 0.003). B Blood MMP-9 value at Y2 with comparison of samples close to the CLAD and distant from the CLAD. Comparison of the MMP-9 plasmatic concentration at Y2 between recipients who developed CLAD within 1 year of measurement, those who developed CLAD at least 1 year after measurement and those who remained stable at least 2 years after measurement with a significant difference between the stable and CLAD groups within 1 year (p = 0.003). Boxplot interpretation: thick horizontal bars correspond to the median, notches to the upper and lower limits of the confidence interval and top and bottom of the box to the first and third interquartile of MMP-9 values. * corresponds to p value < 0.05