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Fig. 3 | Respiratory Research

Fig. 3

From: Fine particulate matter 2.5 induces susceptibility to Pseudomonas aeruginosa infection via expansion of PD-L1high neutrophils in mice

Fig. 3

PM2.5 exposure impaired the phagocytic function of neutrophils in a PD-L1–dependent manner. (A) Ridge plot (left) and UMAP plot (right) showing the distribution of high and low Pdl1 expression with a threshold of 1. (B-C) The UMAP maps showing AUC scores of selected gene signatures (left), and box plots showing AUC scores of selected gene signatures. (D) Apoptosis analysis of PM2.5 treated neutrophils via flow cytometric. (E) Quantifications of (D) are depicted as percentage. (F) Representative images of the phagocytosis process of mCherry-PAO1 by neutrophils. (G) Quantifications of (F) are depicted as phagocytic index. (H) Phagocytic function of neutrophils assessed by neutral red phagocytosis assay. data are shown as means ± SEM. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001

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Respiratory Research

ISSN: 1465-993X

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