Fig. 5
From: Vascular and pulmonary effects of ibuprofen on neonatal lung development
Representative lung sections stained for the macrophage marker CD68 (A–D) or myeloperoxidase (MPO) as a marker for neutrophilic granulocytes (E–H) of rat pups kept in room air (RA; A, B, E and F) or 100% O2 (C, D, G and H). Pups were injected daily with arginine buffer (A, C, E and G) or ibuprofen (50 mg/kg/day; B, D, F and H) until 10 days of age. a = alveolus. The influx of monocytes and macrophages (I) and neutrophilic granulocytes (J) was determined by morphometry on lung sections. RA pups (open symbols) and O2 pups (solid symbols) were injected daily with arginine buffer (circles) or ibuprofen (50 mg/kg/day; triangles) until 10 days of age. Values are expressed as mean ± SEM (N = 6–7). **p < 0.01 and ***p < 0.001 versus RA controls. &p < 0.05 and &&&p < 0.001 versus age-matched arginine buffer-treated O2-exposed controls