Fig. 3

mrIL-11 induces lung fibrosis, pulmonary artery remodeling and hypertension. A A total of 100 µg/Kg/day of rmIL-11 (n = 11) or saline (n = 11) was subcutaneously administered during 21 days. At day 21 the following parameters were measured. A Masson’s trichrome histological images are showed. Scale bar: 100 µm. B Ashcroft score lung fibrotic index, C hydroxyproline amount in lung tissue, D right ventricular systolic pressure (RVSP) mmHg, E right ventricular (RV) hypertrophy measured by the ratio of RV/left ventricular (LV) + septo in mg/mg, F Pulmonary artery remodeling and G inflammatory cells in bronchoalveolar lavage fluid (BALF) were measured. H Co-immunofluorescence of FAP/Tie2-GFP and αSMA/Tie2-GFP. Scale bar: 100 µm. White arrows indicates co-localizations. Data are presented as scatter dot blot with median and interquartile range values. P-values are based on the Mann Whitney test