The original and two new derivative versions of the COMPERA 2.0 risk assessment model: useful tools for guiding balloon pulmonary angioplasty

Zhang, Yi; Li, Xin; Jin, Qi; Luo, Qin; Zhao, Qing; Yang, Tao; Zeng, Qixian; Yan, Lu; Duan, Anqi; Huang, Zhihua; Hu, Meixi; Xiong, Changming; Zhao, Zhihui; Liu, Zhihong

doi:10.1186/s12931-022-02232-1

Table 4 Associations between the original/hybrid 4-stratum model and clinical outcome

From: The original and two new derivative versions of the COMPERA 2.0 risk assessment model: useful tools for guiding balloon pulmonary angioplasty

Outcome	No. of patients	No. of events	Crude HR^d (95% CI)	P for trend
Primary endpoint-clinical worsening
Original 4-stratum model before the 1st BPA
Low	37	1	1 (reference)	< 0.001
Intermediate-low	52	3	2.411 (0.251–23.197)
Intermediate-high	74	18	10.579 (1.411–79.288)
High	12	4	12.524 (1.397–112.234)
Original 4-stratum model after the 1st BPA
Low	77	4	1 (reference)	< 0.001
Intermediate-low	70	10	3.376 (1.057–10.777)
Intermediate-high	25	12	14.716 (4.709–45.989)
High	3	0	NA^a
Hybrid 4-stratum model before the 1st BPA
Low	37	1	1 (reference)	< 0.001
Intermediate-low	52	3	2.418 (0.251–23.264)
Intermediate-high	38	6	5.162 (0.612–42.911)
High	48	16	18.661 (2.471–140.916)
Hybrid 4-stratum model after the 1st BPA
Low	77	4	1 (reference)	< 0.001
Intermediate-low	70	10	3.381 (1.059–10.795)
Intermediate-high	20	9	15.346 (4.684–50.283)
High	8	3	9.113 (2.021–41.100)
Secondary endpoint-achieving low risk^b
Original 4-stratum model before the 1st BPA
Intermediate-low	52	43	1 (reference)	< 0.001
Intermediate-high	74	37	0.209 (0.089–0.490)
High	12	4	0.105 (0.026–0.424)
Hybrid 4-stratum model before the 1st BPA
Intermediate-low	52	43	1 (reference)	< 0.001
Intermediate-high	48	31	0.382 (0.150–0.968)
High	38	10	0.075 (0.027–0.207)
Secondary endpoint-achieving mPAP < 30 mmHg^c
Original 4-stratum model before the 1st BPA
Low	23	12	1 (reference)	< 0.001
Intermediate-low	33	10	0.399 (0.132–1.203)
Intermediate-high	56	9	0.176 (0.059–0.520)
High	7	0	NA^a
Hybrid 4-stratum model before the 1st BPA
Low	23	12	1 (reference)	< 0.001
Intermediate-low	33	10	0.399 (0.132–1.203)
Intermediate-high	42	8	0.216 (0.070–0.663)
High	21	1	0.046 (0.005–0.401)

BPA balloon pulmonary angioplasty, mPAP mean pulmonary arterial pressure
^aNo event happened and HR/OR could not be calculated
^bOnly patients with intermediate-low risk or higher grade at baseline were included in the analysis
^cOnly patients with mPAP ≥ 30 mmHg at baseline were included in the analysis
^dResults of multivariable regression were provided in Additional file 2

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