Table 6 Genes significantly enriched in the Tumor Necrosis Factor pathway. Effect estimates (Bint in mL FEV1) and p-values from the SNP-by-ETS exposure interaction analysis in LifeLines are given
Significant genes in the Tumor Necrosis Factor pathway | ||||
|---|---|---|---|---|
Pathway analysis | SNP-by-ETS exposure interaction | |||
Gene Name | SNP | -log(P-value) | Bint FEV1 (ml) | P-value |
JUN | rs2716129 | 2.45 | −43 | 3.52E-03 |
MAP2K4 | rs2013868 | 2.11 | −51 | 7.73E-03 |
TNFAIP3 | rs11970361 | 1.94 | −95 | 1.14E-02 |
NFKBIE | rs513688 | 1.72 | 37 | 1.91E-02 |
TNFRSF1B | rs235214 | 1.67 | 50 | 2.14E-02 |
FADD | rs10751209 | 1.57 | −33 | 2.71E-02 |
MAP3K7 | rs205349 | 1.47 | 50 | 3.38E-02 |
CASP8 | rs3769823 | 1.47 | 35 | 3.40E-02 |
NFKB1 | rs2085548 | 1.38 | 33 | 4.17E-02 |