Table 5 Genes significantly enriched in the p38 MAPK pathway. Effect estimates (Bint in mL FEV1) and p-values from the SNP-by-ETS exposure interaction analysis are given
Significant genes in the p38 MAPK pathway | ||||
|---|---|---|---|---|
Pathway analysis | SNP-by-ETS exposure interaction | |||
Gene Name | SNP | -log(P-value) | Bint FEV1 (ml) | P-value |
MYC | rs7829529 | 4.23 | 109 | 1.00E-03 |
TGFBR1 | rs12686783 | 3.00 | 71 | 1.39E-03 |
MAP2K6 | rs2716227 | 2.74 | −45 | 2.36E-03 |
MAP2K4 | rs2013868 | 2.63 | −51 | 7.73E-03 |
CREB1 | rs722761 | 2.52 | −38 | 1.38E-02 |
MAPK14 | rs851023 | 2.47 | 52 | 1.47E-02 |
MEF2A | rs7164257 | 2.45 | −55 | 1.80E-02 |
MAP3K9 | rs731571 | 2.11 | 42 | 2.01E-02 |
TGFB2 | rs2798631 | 1.91 | 35 | 2.05E-02 |
HSPB1 | rs2908201 | 1.86 | −39 | 2.22E-02 |
MAX | rs2763887 | 1.75 | −67 | 3.32E-02 |
MAP3K7 | rs205349 | 1.75 | 50 | 3.38E-02 |
MAP3K5 | rs2237268 | 1.72 | 32 | 3.41E-02 |
PLA2G4A | rs10489409 | 1.67 | −53 | 3.81E-02 |
MAPKAPK2 | rs11119447 | 1.64 | −32 | 3.87E-02 |
HMGN1 | rs2836992 | 1.57 | −31 | 3.93E-02 |