Table 3 Significantly (FDR p-value <0.05) and suggestively (FDR p-value <0.25) enriched pathways based on genome-wide interaction SNP-by-ETS exposure p-values within 100 kb of the gene using i-GSEA-4-GWAS [15]
Pathway/Gene set name | Description | FDR corrected p-value | Significant genes/ Selected genes/All genes |
|---|---|---|---|
Apoptosis | Apoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. | 0.003 | 22/54/71 |
P38 MAPK pathway | The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. | 0.063 | 16/33/40 |
Tumor Necrosis Factor pathway | Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. | 0.081 | 9/22/29 |