Table 3 Coefficients (95%-confidence intervals) of regression models adjusted for covariates that remained stable in replication analyses
Spirometric parameter indicative of | Lung volume | Airways & volume | Airflow limitation | Airways |
|---|---|---|---|---|
FVC, ml | FEV1, ml | FEV1/FVC, % | FEF25–75, ml/s | |
Sex, male | 347 (289, 405) | 220 (167, 274) | −2.2 (−2.9,-1.4) | |
Age, IQR years | 47 (26, 69) | 30 (11, 50) | ||
Height, IQR cm | 637 (598, 676) | 517 (481, 553) | 508 (438, 577) | |
Early life events | ||||
Peak weight velocity, IQR kg/month | −0.8 (−1.3, −0.3) | −88 (−155, −20) | ||
Lung infections (up to age 3), yes | −55 (−102, −7) | −1.1 (−1.8,-0.3) | −159 (−258, −60) | |
Environment & lifestyle at age 15 | ||||
Regular indoor second-hand smoke exposurea, yes | −59 (−114, −5) | |||
Serum vitamin Db, IQR nmol/l | 65 (34, 96) | 32 (3, 61) | −0.6 (−1, −0.2) | |
Body mass index, IQR kg/m2 | 222 (194, 250) | 144 (118, 171) | −1.2 (−1.6,-0.8) | 85 (31, 140) |
Allergic diseases at age 15 | ||||
Asthma, yes | −118 (−216, −21) | −177 (−268, −86) | −1.8 (−3.1,-0.4) | −304 (−494, −115) |
Study specific | ||||
Study (LISAplus vs GINIplus) | 68 (12, 124) | |||
Study center (Wesel vs Munich) | −66 (−119, −13) | −135 (−182, −88) | −1.6 (−2.3,-0.9) | −256 (−352, −161) |