Skip to main content

Table 6 Biomarkers associated with mortality

From: Multiple biomarkers predict disease severity, progression and mortality in COPD

 

COPDGene

ECLIPSE

Biomarker(s)

β

R2

AIC

β

R2

AIC

None

 

0.56

1568

 

0.31

3062

CC16

−0.91

0.01

1565*

0.06

0.02

2874

SP-D

0.96

0.02

1565*

0.79

0.03

2868*

sRAGE

0.43

0.00

1555

0.45

−0.03

1754

CRP

0.21

0.00

1569

0.36

0.01

2900*

Fibrinogen

−0.59

0.00

1528

1.61

0.02

2502*

CRP, Fibrinogen, SP-D

 

0.04

1523*

 

0.06

2249*a

CC16, CRP, Fibrinogen, SP-D, sRAGE

 

0.04

1509*a

 

−0.02

1276

  1. Analysis performed by Cox Proportional Hazards. Covariates were BODE, age2, gender, and severe exacerbations. The R2 reported for clinical covariates (no biomarkers) is given. The R2 reported for biomarkers refers to the R2 of the biomarkers(s) over clinical covariates alone. *p < 0.02 in a two-sided t-test for the null hypothesis that β = 0
  2. aBest model
Back to article page

Respiratory Research

ISSN: 1465-993X

Contact us