Fig. 4From: In smokers, Sonic hedgehog modulates pulmonary endothelial function through vascular endothelial growth factorEffect of VEGF on endothelium- and NO-dependant pulmonary relaxation. Treatment with VEGF strongly enhanced the relaxant response to Ach (nā=ā6). This effect was endothelium- and NO- dependent, as shown by the full inhibitory effect of either endothelium removal (Endoth-) or incubation with a NO synthase inhibitor (L-NAME)Back to article page