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Table 1 Patient Characteristics

From: Reduced HDAC2 in skeletal muscle of COPD patients

 

Non smokers

Smokers without COPD

COPD

N

4

8

12

Age (yr)

63 ± 10

67 ± 9

66 ± 6

Sex (F:M)

1:3

2:6

0:15

Smoking status (current/ex/never)

0/0/4

2/6/0

1/11/0

Pack-year

0 ± 0

16 ± 22

40 ± 23

BMI (kg/m2)

23 ± 2

30 ± 7

25 ± 5

FEV1 (L)

3.00 ± 0.91

2.91 ± 0.41

1.05 ± 0.37a, b

FEV (%predicted)

104 ± 15

107 ± 20

33 ± 11 a, b

RV %predicted (%)

ND

ND

207 ± 40

KCO %predicted (%)

ND

ND

52 ± 19

MVC (kg)

40 ± 19

41 ± 13

34 ± 10

PaO2 (kPa)

ND

ND

8.7 ± 2.2

Systemic Steroids

NA

NA

0

ICS

NA

NA

5

  1. Abbreviations: BMI body mass index, FEV 1 forced expiratory volume in 1 s, RV residual volume, KCO carbon monoxide transfer coefficient, MVC maximum voluntary contraction, PaO 2 partial pressure of oxygen in arterial blood, ICS inhaled corticosteroid, COPD chronic obstructive pulmonary disease, ND not determined, NA not applicable
  2. a p < 0.01 compared to NS; b p < 0.01 compared to SM