Fig. 2

NF-κB DNA binding activity in skeletal muscle biopsy specimens. a NF-κB DNA binding activity was measured in whole cell extracts from skeletal muscle biopsies. Correlation between NF-κB DNA binding activity and FEV₁ %predicted (b), cigarette exposure in pack-years (c). HDAC2 protein expression (d) and HDAC5 protein expression (e). Abbreviations: healthy non-smokers (NS), smokers without COPD (SM), chronic obstructive pulmonary disease (COPD), nuclear factor-kappa B (NF-κB), forced expiratory volume in 1 s (FEV ₁ ), maximum voluntary contraction (MVC)