Table 3 Expression levels of the top 20 of potential stem cell-related genes that showed a higher mRNA expression in the NEB ME compared to CAE in PCR arrays
Gene | Gene name | Fold regulation | Location | Function | Family |
|---|---|---|---|---|---|
Dll3 | Delta-like ligand 3 (Drosophila) | 359.86 | Membrane | Developmental protein | Notch |
Mapk10 | Mitogen-activated protein kinase 10 | 257.01 | Cytoplasm | Serine/threonine-protein transferase | Protein kinase |
Lef1 | Lymphoid enhancer binding factor 1 | 69.31 | Nucleus | Transcription regulation | Wnt |
Lor | Loricrin | 58.95 | Cytoplasm | Structural constituent of cytoskeleton | TCF/LEF |
Fgf14 | Fibroblast growth factor 14 | 40.80 | Nucleus | Growth factor | Hepann-binding growth factor |
Fgf5 | Fibroblast growth factor 5 | 39.69 | Secreted | Growth factor, mitogen | Heparin-binding growth factor |
Disp2 | Dispatched homolog 2 (Drosophila) | 29.24 | Membrane | Component of membrane | Dispatched |
Bmp2 | Bone morphogenetic protein 2 | 27.10 | Secreted | Cytokine, developmental protein, growth factor | TGFß |
Plg | Plasminogen | 25.50 | Secreted | Hydrolase, protease, serine protease | Peptidase S1 |
Wnt16 | Wingless-related MMTV integration site 16 | 19.57 | Cytoplasm | Developmental protein | Wnt |
Spp1 | Secreted phosphoprotein 1 | 17.28 | Secreted | Cytokine | Osteopontin |
Nanog | Nanog homeobox | 13.64 | Nucleus | Developmental protein, transcription regulation | Nanog homeobox |
Mstn | Myostatn | 13.09 | Secreted | Cytokine, growth factor | TGFß |
Ptgs2 | Prostaglandin-endoperoxide synthase 2 | 12.75 | Membrane | Oxidoreductase. peroxidase | Prostaglandin G/H synthase |
ll10 | Interleukin 10 | 11.73 | Secreted | Cytokine | ll10 |
Gli3 | GLI-Kruppel family member GLI3 | 11.27 | Nucleus | Transcription regulation | GLI C2H2-type zinc-finger protein |
Bmp7 | Bone morphogenetic protein 7 | 11.21 | Secreted | Cytokine, developmental protein. gro\Mh factor | TGFfß |
Fgf22 | Fibroblast growth factor 22 | 10.71 | Secreted | Growth factor | Hepann-binding growth factor |
Igf2 | Insulin-like growth factor 2 | 9.19 | Secreted | Growth factor, hormone, mitogen | Insulin |
Fgf9 | Fibroblast growth factor 9 | 8.28 | Secreted | Developmental protein, growth factor, mitogen | Heparin-binding growth factor |