Skip to main content

Table 2 Hemodynamic and IVUS data in control subjects and patients with COPD and ILD with or without pulmonary hypertension

From: Pulmonary arterial wall disease in COPD and interstitial lung diseases candidates for lung transplantation

 

Chronic Obstructive Pulmonary Disease

Interstitial Lung Disease

Control

 

All (18)

Non PH (10)

PH (8)

All (28)

Non PH (15)

PH (13)

(10)

mPAP, mm Hg

26 ± 2*

21 ± 1*

33 ± 3*#

27 ± 2*

20 ± 1*

32 ± 3*

15 ± 2

pPAP, mm Hg

16 ± 2*

14 ± 1

18 ± 3*

23 ± 2*§

17 ± 0.9*

27 ± 4*#§

11 ± 3

CI, L/min/m2

2.5 ± 0.2

2.3 ± 0.2*

2.5 ± 0.2

2.5 ± 0.1

2.5 ± 0.1

2.5 ± 0.1

2.6 ± 0.1

HR, bpm

76 ± 3

72 ± 4

82 ± 4.4

81 ± 2.6

80 ± 4

83 ± 3

73 ± 1.3

SV, mL

57 ± 2

54 ± 3

56 ± 4

60 ± 2

61 ± 3

59 ± 3

64 ± 2

RAP, mm Hg

8.7 ± 0.7*

7.4 ± 0.7*

10.8 ± 1.2*#

5.4 ± 0.6§

5.2 ± 0.8

6.1 ± 0.4§

5.0 ± 1.2

PAWP, mm Hg

10.9 ± 0.7

10.0 ± 1.0

11.6 ± 0.7*

8.0 ± 0.5§

7.7 ± 0.8

9.0 ± 0.8§

8.8 ± 0.6

PVR, Wu

3.3 ± 0.3

2.9 ± 1.3

3.9 ± 0.5*

4.1 ± 0.4*

2.9 ± 0.4

5.6 ± 0.4*§#

3.0 ± 0.3

TPR, Wu

6.3 ± 0.6*

5.8 ± 0.6*

7.1 ± 1.1*

6.2 ± 0.5*

4.7 ± 0.4*

8.2 ± 0.6*#

3.3 ± 0.25

Cp, mL/mmHg

4.2 ± 0.28*

4.3 ± 0.3*

3.0 ± 0.7*#

2.9 ± 0.2*§

3.5 ± 0.2*

2.1 ± 0.1*§

6.2 ± 0.4

RC time, sec

0.8 ± 0.05*

0.67 ± 0.06*

0.98 ± 0.1*#

0.6 ± 0.02*§

0.55 ± 0.04*

0.69 ± 0.07*#

1.1 ± 0.03

EM, mm Hg

64 ± 5*

51 ± 5*

79 ± 9*#

105 ± 7*§

90 ± 7*§

124 ± 11*§#

21 ± 1.7

AWT, %

23 ± 1*

19 ± 1*

24 ± 1*

17 ± 1*§

18 ± 1*

15 ± 1 *§#

1.4 ± 1.3

  1. Data are mean ± SEM
  2. Abbreviations: AWT area wall thickness, CI cardiac index, Cp total pulmonary arterial capacitance, EM elastic modulus, HR heart rate, mPAP and pPAP mean and pulsatile pulmonary arterial pressure, respectively, PAWP pulmonary arterial wedge pressure, PVR pulmonary vascular resistance; SV: stroke volume, RAP right atrial pressure, TPR total pulmonary resistance
  3. *p < 0.05 vs. Control; §p < 0.05 vs. COPD; #p < 0.05 vs. Non PH