Rescue medication use as a patient-reported outcome in COPD: a systematic review and regression analysis

Respiratory Research

Table 3 Pearson correlation coefficients between rescue medication use and other COPD outcomes

Outcome	Mean change from baseline in number of puffs/day		Mean change from baseline in % of rescue-free days
Outcome	N	Pearson correlation coefficient [95% CI], p-value	N	Pearson correlation coefficient [95% CI], p-value
Mean change from baseline in trough FEV₁
6 months	64	−0.66 [−0.78, −0.49], <0.0001	33	0.43 [0.10, 0.67], 0.0118
Study end	94	−0.74 [−0.82, −0.64], <0.0001	46	0.63 [0.41, 0.77], <0.0001
Mean change from baseline in SGRQ score
6 months	50	0.60 [0.33, 0.72], <0.0001	18	−0.42 [−0.74, 0.05], 0.077
Study end	75	0.78 [0.67, 0.86], <0.0001	31	−0.70 [−0.84, −0.46], <0.0001
Mean TDI
6 months	57	−0.43 [−0.62, −0.19], 0.0007	24	0.69 [0.40, 0.86], <0.0001
Study end	54	−0.43 [−0.63, −0.19], 0.0009	24	0.69 [0.40, 0.86], <0.0001
Mean annualized rate of moderate or severe exacerbations
6 months	17	0.66 [0.27, 0.87], 0.0028	11	Insufficient data
Study end	38	0.66 [0.44, 0.81], <0.0001	24	−0.39 [−0.68, 0.02], 0.0619

These analyses were weighted by study treatment group sample size, and included all trial arms
Abbreviations: CI confidence interval, COPD chronic obstructive pulmonary disease, FEV ₁ forced expiratory volume in one second, SGRQ St George’s Respiratory Questionnaire, TDI Transition Dyspnoea Index

ISSN: 1465-993X