Table 2 Differences and similarities in clinical features between sputum eosinophilhigh and AC patients
From: Clinical characteristics of eosinophilic COPD versus COPD patients with a history of asthma
AC n = 14 | Sputum Eosinophilhigh subgroup n = 24 | p value | |
|---|---|---|---|
Gender (% Male) | 79 | 75 | >0.99 |
Age (years) | 57.0 (6.9) | 68.3 (7.9) | <0.0001 |
BMI (kg/m2) | 29.1 (4.5) | 27.1 (4.5) | 0.19 |
FFMI(kg/m2) | 16.8 (2.7) | 17.2 (3.7) | 0.70 |
Smoking history (% Ex) | 71 | 58 | 0.51 |
Pack years | 33.7 [13.5–69.8] | 46.3 [16.8–154.0] | 0.06 |
Exacerbation (12mths prior) | 3 [0–5] | 1 [0–5] | 0.02 |
Chronic bronchitis (%) | 86 | 71 | 0.44 |
Any comorbidities (%) | 85 | 79 | >0.99 |
Age COPD diagnosis | 50.7 (5.9) | 62.7 (7.7) | <0.0001 |
Duration of COPD diagnosis (years) | 8 [0.5–16.0] | 5.5 [2.0–17.0] | 0.71 |
ICS use (%) | 93 | 79 | 0.38 |
ICS dose (BDP equivalent) | 1550 [0–2000] | 1000 [0–2000] | 0.60 |
SGRQ total | 34.0 [15.3–78.8] | 51.5 [6.0–90.5] | 0.34 |
CAT | 19.3 (8.8) | 18.9 (9.9) | 0.90 |
CCQ total | 1.8 [0.6–5.1] | 2.5 [0.5–4.7] | 0.74 |
Skin prick positive to >1 allergen (%) | 50 | 0 | 0.0003 |
Allergic rhinitis (%) | 0 | 8.7 | 0.52 |
Hayfever (%) | 57.1 | 12.5 | 0.008 |
Eczema (%) | 35.7 | 25.0 | 0.71 |
Yes to do you suffer from allergies? (%) | 85.7 | 8.3 | <0.0001 |
Family history of asthma (%) | 53.8 | 36.4 | 0.48 |
Total IgE (IU/ml) | 156 [2–2458] | 69.5 [2–1868] | 0.30 |
High IgE (>100 IU/ml) | 50.0 | 71.4 | 0.74 |
Pre FEV1 (L) | 1.8 (0.7) | 1.2 (0.4) | 0.003 |
Pre FEV1 (%) | 55.3 (16.6) | 44.8 (14.4) | 0.048 |
Pre FEV1/FVC | 0.5 (0.1) | 0.3 (0.1) | <0.001 |
Post FEV1 (L) | 2.0 (0.7) | 1.3 (0.4) | 0.003 |
Post FEV1 (%) | 61.5 (16.5) | 51.0 (14.1) | 0.04 |
Post FEV1/FVC | 0.5 (0.1) | 0.4 (0.1) | <0.001 |
Reversibility % | 8.1 [-4.9–30.4] | 15.7 [0–48.2] | 0.15 |
Reversibility (ml) | 175.0 [-100.0–510.0] | 125.0 [-60.0–400.0] | 0.87 |
BDR ≥12% and 200ml (%) | 28.6 | 37.5 | 0.73 |
BDR ≥15% and 400ml (%) | 14.3 | 4.2 | 0.54 |
Raw (kPa.sec) | 0.4 (0.2) | 0.6 (0.2) | 0.11 |
sGaw (kPa.sec) | 0.4 [0.2–1.1] | 0.4 [0.1–1.2] | 0.30 |
VC % | 89.8 [77.9–111.5] | 88.9 [65.8–129.5] | 0.60 |
TLC% | 106.9 (16.4) | 112.3 (17.0) | 0.38 |
RV % | 145.3 (51.7) | 151.1 (64.5) | 0.79 |
IC % | 82.1 (14.0) | 67.4 (12.3) | 0.004 |
FRC % | 125.5 (26.5) | 138.9 (48.5) | 0.37 |
KCO % | 79.2 (13.3) | 75.6 (19.8) | 0.56 |
6MWD (metres) | 376.4 (73.8) | 330.4 (95.1) | 0.16 |
FeNO 50 (ppb) | 11.3 [5.2–56.0] | 14.3 [7.0–40.3] | 0.25 |
Blood eosinophil count (109/L) | 0.22 [0.10–0.53] | 0.25 [0.06–1.14] | 0.37 |
Blood eosinophil % | 3.5 [0.9–7.8] | 3.4 [0.9–20.7] | 0.97 |
Blood eosinophil >5% | 14.3 | 25.0 | 0.68 |
Blood eosinophil count ≥300 cells/μl | 35.7 | 41.7 | >0.99 |
Sputum total cell count ×106/g | 3.3 [1.0–21.2] | 5.9 [0.5–33.0] | 0.04 |
Sputum neutrophil % | 68.8 [27.5–91] | 77.8 [48.0–92.0] | 0.14 |
Sputum macrophage % | 21.2[6.8–44.0] | 14.8 [1.2–32.3] | 0.03 |
Sputum eosinophil % | 2.5 [0.5–9.3] | 6.0 [3.2–16.3] | 0.0004 |
Sputum lymphocyte % | 0.3 [0.0–4.5] | 0.0 [0.0–1.0] | 0.06 |
Sputum epithelial cells % | 2.8 [0.3–27.5] | 1.0 [0.0–13.0] | 0.08 |
Sputum neutrophil cell count ×106/g | 2.5 [0.3–17.5] | 4.7 [0.3–29.4] | 0.04 |
Sputum macrophage cell count ×106/g | 0.6 [0.2–2.1] | 0.6 [0.1–3.9] | 0.67 |
Sputum eosinophil cell count ×106/g | 0.1 [0.01–1.3] | 0.04 [0.02–1.3] | 0.001 |
Sputum lymphocyte cell count ×106/g | 0.01 [0.0–0.06] | 0.0 [0.0–0.17] | 0.29 |
Sputum epithelial cell count ×106/g | 0.2 [0.0–0.9] | 0.07 [0.0–0.89] | 0.08 |
Sputum eosinophil ≥3% | 46.2 | 100 | 0.0002 |
Bacterial load (genome copies/ml) | 4.97×104 [0.00–2.06×106] | 5.52×104 [0.00–1.24×107] | 0.66 |
Colonised (sum bacterial load ≥1×104) (%) | 83 | 67 | 0.44 |