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Fig. 8 | Respiratory Research

Fig. 8

From: Dibutyryl-cAMP attenuates pulmonary fibrosis by blocking myofibroblast differentiation via PKA/CREB/CBP signaling in rats with silicosis

Fig. 8

Proposed Mechanism of cAMP Anti-Fibrotic Effects. Anti-fibrotic effects of cAMP are proposed to involve 1) increased PKA and p-CREB, 2) down-regulation of p-Smad2/3 binding to CBP, 3) concomitant reduced activation of p-Smads and the Smad-induced genes, Collagen I, Fn and α-SMA in induced fibroblasts, and 4) a resultant inhibition of myofibroblast differentiation

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Respiratory Research

ISSN: 1465-993X

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