Fig. 1

Myofibroblast differentiation and ECM deposition is regulated by db-cAMP. a Lung tissue stained with HE staining; b Lung tissue stained with Van Gieson staining; c Immunohistochemical measurement of α-SMA expression in rat lung silicosis tissue; d Percentage of silicotic nodule area and number of silicotic nodule; e Fn, Col I and α-SMA expression in lung tissue (Western blot). Data are means ± SEM; n = 6 independent experiments; f Fn, Col I and α-SMA expression in fibroblasts (Western blot). Data are means ± SEM; n = 6 independent experiments