Table 1 Representative genes that were increased more than 4-fold by IL-13 according to the global gene expression analysis (see Figure 4.)
From: Clarithromycin attenuates IL-13–induced periostin production in human lung fibroblasts
(A) Cluster | Gene Symbol | CAM effect |
Extracellular | PLXDC1 | 0.0342 |
Extracellular | SLIT2 | 0.4594 |
Extracellular | POSTN | 0.4979 |
Extracellular | WNT10B | 0.4239 |
Plasma membrane | CACNA1D | 0.0807 |
Plasma membrane | RTP1 | 0.1379 |
Plasma membrane | SYT8 | 0.2078 |
Plasma membrane | RALGPS1 | 0.2754 |
Plasma membrane | APC | 0.2138 |
Defense response | CD40 | 0.0131 |
Defense response | NOS2 | 0.3132 |
Defense response | CD19 | 0.1667 |
Defense response | IFNL1 | 0.0426 |
Defense response | CXCL1 | 0.2197 |
(B) Cluster | Gene Symbol | CAM effect |
Glycoprotein | IL17RA | 0.9564 |
Glycoprotein | ST8SIA1 | 0.6773 |
Glycoprotein | SPINT2 | 0.8788 |
Glycoprotein | IL1RL1 | 0.7990 |
Glycoprotein | SULF1 | 0.5449 |
Glycoprotein | APLNR | 1.0210 |
Glycoprotein | HS3ST1 | 0.9854 |
Chemotaxis | CCL26 | 1.2418 |
Chemotaxis | IL6 | 0.8210 |
Chemotaxis | PTGDR2 | 0.7217 |
Signal regulator | SOCS1 | 1.1385 |
Signal regulator | CISH | 0.8930 |
(C) Cluster | Gene Symbol | IL-13 effect |
Chemotaxis | CCL26 | 35.6732 |
Glycoprotein | HS3ST1 | 12.2410 |
Glycoprotein | ST8SIA1 | 10.7933 |
Chemotaxis | IL6 | 10.1221 |
Signal regulator | CISH | 8.9751 |
Chemotaxis | PTGDR2 | 7.2666 |
Unassigned | LINC00971 | 7.2156 |
Signal regulator | SOCS1 | 6.3270 |
Glycoprotein | IL17RA | 5.9221 |
Extracellular | SLIT2 | 5.7987 |
(D) Cluster | Gene Symbol | CAM effect |
Plasma membrane | SLC22A20 | 0.1237 |
Unassigned | XLOC_006850 | 0.1403 |
Unassigned | XLOC_014512 | 0.1420 |
Unassigned | SPDYE8P | 0.1491 |
Defense response | CD19 | 0.1667 |
Unassigned | LOC100129675 | 0.1696 |
Unassigned | LOC102724783 | 0.1880 |
Plasma membrane | SYT8 | 0.2078 |
Centriole | SASS6 | 0.2079 |
Plasma membrane | APC | 0.2138 |