Admission levels of asymmetric and symmetric dimethylarginine predict long-term outcome in patients with community-acquired pneumonia

Vögeli, Alaadin; Ottiger, Manuel; Meier, Marc A.; Steuer, Christian; Bernasconi, Luca; Kulkarni, Prasad; Huber, Andreas; Christ-Crain, Mirjam; Henzen, Christoph; Hoess, Claus; Thomann, Robert; Zimmerli, Werner; Mueller, Beat; Schuetz, Philipp

doi:10.1186/s12931-017-0502-4

Table 4 Multivariate associations of initial biomarker levels with demographic characteristics and comorbidities^a

From: Admission levels of asymmetric and symmetric dimethylarginine predict long-term outcome in patients with community-acquired pneumonia

	Arginine		ADMA		SDMA		Arginine/ADMA ratio
	Coefficient (95% CI)	p value	Coefficient (95% CI)	p value	Coefficient (95% CI)	p value	Coefficient (95% CI)	p value
Patient characteristics
Age in decades	0.01 (−0.02 to 0.03)	0.490	0.03 (0.02 to 0.05)	<0.001	0.04 (0.01 to 0.07)	0.012	−0.02 (−0.05 to −0.002)	0.035
Female	0.0001 (−0.08 to 0.08)	0.997	0.02 (−0.04 to 0.07)	0.506	0.02 (−0.07 to 0.12)	0.639	−0.04 (−0.11 to 0.03)	0.277
BMI	−0.01 (−0.01 to 0.0004)	0.066	0.003 (−0.002 to 0.01)	0.300	0.00 (−0.01 to 0.01)	0.819	−0.01 (−0.01 to −0.003)	0.005
Systolic BP in 10 mmHg	0.01 (−0.0003 to 0.03)	0.118	0.001 (−0.01 to 0.01)	0.847	−0.01 (−0.04 to 0.01)	0.195	0.01 (−0.004 to 0.03)	0.154
Comorbidities
Coronary artery disease	−0.08 (−0.18 to 0.03)	0.160	−0.05 (−0.12 to 0.02)	0.142	−0.02 (−0.15 to 0.10)	0.703	−0.02 (−0.11 to 0.07)	0.605
Congestive heart failure	−0.02 (−0.14 to 0.10)	0.723	0.02 (−0.06 to 0.10)	0.641	0.10 (−0.05 to 0.24)	0.194	−0.06 (−0.17 to 0.04)	0.213
Cerebrovascular disease	0.02 (−0.13 to 0.17)	0.776	−0.02 (−0.12 to 0.08)	0.688	−0.003 (−0.19 to 0.18)	0.970	0.02 (−0.1 to 0.15)	0.726
PAOD	−0.02 (−0.21 to 0.16)	0.814	−0.10 (−0.22 to 0.02)	0.101	0.03 (−0.19 to 0.25)	0.771	0.06 (−0.09 to 0.21)	0.415
Chronic renal failure	0.02 (−0.08 to 0.12)	0.659	0.01 (−0.06 to 0.08)	0.807	0.22 (0.09 to 0.34)	0.001	−0.00008 (−0.09 to 0.09)	0.999
Diabetes mellitus	0.02 (−0.09 to 0.13)	0.701	−0.004 (−0.08 to 0.07)	0.923	0.06 (−0.08 to 0.20)	0.406	−0.03 (−0.13 to 0.07)	0.596
Neoplastic disease	0.07 (−0.05 to 0.19)	0.274	0.09 (0.01 to 0.17)	0.024	0.11 (−0.04 to 0.25)	0.144	−0.06 (−0.16 to 0.04)	0.273
COPD	−0.02 (−0.11 to 0.06)	0.593	−0.06 (−0.12 to 0.001)	0.056	0.11 (0.001 to 0.22)	0.047	0.04 (−0.04 to 0.11)	0.345

Data for multivariate linear regression analyses are given as coefficient (95% CI)
Bolded p values are statistically significant at p < 0.05
Abbreviations: ADMA asymmetric dimethylarginine, BMI body mass index, CI confidence interval, COPD chronic obstructive pulmonary disease, PAOD peripheral artery occlusive disease, SDMA symmetric dimethylarginine
^aMultivariate model: adjusted for patient age and comorbidities (coronary artery disease, congestive heart failure, cerebrovascular disease, PAOD, chronic renal failure, diabetes mellitus, neoplastic disease, COPD)

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ISSN: 1465-993X

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