Lymphoid cell and follicle quantification (expressed as cells or follicles/mm2 area) | |||
---|---|---|---|
Control subjects | CF patients | Mann-Whitney U test | |
CD4 T cells | 3.8 (0.6–7.6) | 9.0 (2.9–21.7) | 0.007** |
Cytotoxic T cells (CD8) | 1.5 (0.2–11.4) | 55.8 (23.7–71.5) | <0.0001*** |
B cells (CD20) | 0.0 (0.0–0.9) | 0.3 (0.1–0.8) | 0.091 |
Lymphoid follicles | 0.0 (0.0–0.009) | 0.056 (0.022–0.082) | <0.0001*** |
Airway | 0.0 (0.0–0.003) | 0.014 (0.006–0.029) | <0.0001*** |
Parenchyma | 0.0 (0.0–0.003) | 0.011 (0.006–0.039) | <0.0001*** |
Perivascular | 0.0 (0.0–0.003) | 0.011 (0.004–0.023) | 0.0002*** |