Gene symbol | Gene name | Fold change COPD/Smokers | Function |
---|---|---|---|
Upregulation | |||
CD177 | CD177 molecule | 22.59 | Leukocyte migration |
MUC17 | Mucin 17, cell surface associated | 21.54 | Extracellular matrix constituent |
IL1R2 | Interleukin 1 receptor, type II | 10.96 | Decoy receptor, inhibits the activity of IL-1 |
SARDH | Sarcosine dehydrogenase | 9.52 | Mitochondrial matrix |
EGR3 | Early growth response 3 | 6.75 | Positive regulation of endothelial cell proliferation |
AREG | Amphiregulin | 6.16 | EGF family, promote the growth of normal epithelial cells |
SLC6A2 | Solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 | 4.70 | Sodium symporter |
TMEM167A | Transmembrane protein 167A | 4.55 | Golgi apparatus |
KCNJ15 | Potassium inwardly-rectifying channel, subfamily J, member 15 | 4.42 | Potassium channel activity |
FCHO1 | FCH domain only 1 | 4.39 | Clathrin-mediated endocytosis |
Downregulation | |||
IL1A | Interleukin 1, alpha | −44.69 | Immune response |
IL6 | Interleukin 6 (interferon, beta 2) | −16.14 | Pro-inflammatory and anti-inflammatory role |
CXCL10 | Chemokine (C-X-C motif) ligand 10 | −15.08 | leukocyte chemotaxis |
TNF | Tumor necrosis factor | −11.79 | Inflammation, cause apoptosis |
CCL20 | Chemokine (C-C motif) ligand 20 | −7.94 | Lymphocytes chemotaxis |
CCL4 | Chemokine (C-C motif) ligand 4 | −6.19 | Leukocyte chemotaxis |
CCL3L3 | Chemokine (C-C motif) ligand 3-like 3 | −5.28 | Leukocyte chemotaxis |
C9orf7 | Chromosome 9 open reading frame 7 | −5.23 | Calcium channel activity |
IL1RN | Interleukin 1 receptor antagonist | −4.69 | Inhibition of the activities of IL-1 |
RNF19B | Ring finger protein 19B | −4.17 | Cytotoxic effects of natural killer (NK) cells |