From: The impact of low-frequency, low-force cyclic stretching of human bronchi on airway responsiveness
 |  | Cyclic stretch effect on the basal tone during stretching period, difference between control and stretch group | Effect of pretreatment | Effect size pretreatment | |
---|---|---|---|---|---|
n | in absence of pretreatment (g) | in presence of pretreatment (g) | (g) | |d| [95% CI] | |
Epithelium removal | 13 | 0.76 ± 0.08a | 0.53 ± 0.10a | −0.23 ± 0.09 d | −0.70 [−1.48 − 0.10] |
Indomethacin (1 μM) | 8 | 1.14 ± 0.2b | 1.14 ± 0.18a | 0.01 ± 0.10 | 0.00 [−1.01 − 1.01] |
MK476 (1 μM) | 7 | 1.22 ± 0.2b | 0.89 ± 0.14a | −0.33 ± 0.12d | −0.68 [−1.70 − 0.44] |
L-NAME (1 mM) | 14 | 0.61 ± 0.15b | 1.18 ± 0.15a | 0.57 ± 0.14e | 1.02 [0.20 − 1.77] |
Nicardipine (10 μM) | 10 | 0.65 ± 0.12a | 1.03 ± 0.18a | 0.38 ± 0.18 | 0.78 [−0.16 − 1.66] |
Tetrodotoxin (1 μM) | 7 | 1.07 ± 0.19b | 1.29 ± 0.28b | 0.22 ± 0.16 | 0.35 [−0.73 − 1.38] |
Gadolinium (0.1 mM) | 8 | 1.18 ± 0.20a | 1.24 ± 0.15a | 0.06 ± 0.18 | 0.12 [−0.87 − 1.10] |
Tertiapine (10 μM) | 9 | 0.51 ± 0.13b | −0.74 ± 0.12a | −1.25 ± 0.17f | −3.32 [−4.50− −1.85] |
Capsazepine (1 μM) | 8 | 1.19 ± 0.14a | 0.92 ± 0.20b | −0.26 ± 0.23 | −0.67 [−1.31− −0.01] |
Calphostine C (0.1 μM) | 9 | 1.10 ± 0.23a | 1.12 ± 0.25b | 0.02 ± 0.29 | 0.03 [−0.90 − 0.95] |
SB203580 (0.1 μM) | 10 | 1.11 ± 0.27b | 0.84 ± 0.42 | −0.27 ± 0.37 | −0.24 [−1.11 − 0.65] |
Y27632 (1 μM) | 11 | 1.10 ± 0.25b | −0.75 ± 0.30c | −1.85 ± 0.50e | −2.03 [−2.96– − 0.93] |