Table 5 Percentagea of OPCRD patients with COPD eligible for RCTs testing other single treatmentsb (n = 36 893)
Step | Criterion for sequential selection | NCT00134979 (Fa) | NCT00363896 (Aa) | NCT01001494 (A) | NCT01044459 (A) | NCT00463567 (Ia) | NCT00567996 (I) | NCT00792805 (I) | NCT00845728 (I) | NCT00782210 (Oa) | NCT00793624 (O) | NCT00929110 (Ga) | NCT01005901 (G) | NCT01566604 (G) | Median |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | FEV1 | 63.9 | 80.7 | 76.5 | 76.5 | 76.5 | 76.5 | 76.5 | 23.0 | 80.7 | 80.7 | 76.5 | 76.5 | 76.5 | 76.5 |
2 | Other inclusion criteria | 51.4 | 68.3 | 64.9 | 64.9 | 71.4 | 72.3 | 72.3 | 12.5 | 76.4 | 76.4 | 59.1 | 72.3 | 57.8 | 68.3 |
3 | COPD related exclusion criteria | 50.5 | 67.1 | 64.3 | 63.8 | 57.8 | 68.8 | 65.0 | 10.1 | 75.6 | 74.9 | 56.5 | 70.2 | 51.1 | 64.3 |
4 | Concomitant pulmonary disease | 44.8 | 60.8 | 58.3 | 57.9 | 52.6 | 62.4 | 58.3 | 8.8 | 74.8 | 70.9 | 51.0 | 62.7 | 46.2 | 58.3 |
5 | Asthma, allergic diseases and atopy | 34.7 | 43.8 | 46.0 | 45.7 | 42.0 | 44.6 | 46.0 | 6.8 | 72.5 | 66.5 | 38.0 | 49.2 | 34.2 | 44.6 |
6 | Comorbidities | 26.5 | 42.6 | 44.7 | 38.2 | 32.0 | 36.0 | 43.3 | 6.5 | 55.0 | 61.9 | 28.3 | 47.8 | 25.7 | 38.2 |
7 | Other relevant conditions | 26.3 | 41.5 | 44.7 | 38.2 | 31.7 | 34.9 | 43.3 | 6.5 | 55.0 | 57.6 | 28.1 | 47.8 | 25.2 | 38.2 |
8 | Final eligible proportion (%) | 26.3 | 41.5 | 44.6 | 38.1 | 26.2 | 34.9 | 43.3 | 6.5 | 55.0 | 57.6 | 23.1 | 39.2 | 20.7 | 38.1 |