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Fig. 8 | Respiratory Research

Fig. 8

From: Inflammation and emphysema in cigarette smoke-exposed mice when instilled with poly (I:C) or infected with influenza A or respiratory syncytial viruses

Fig. 8

CS injury induces MMP12 in the lungs in response to IAV or RSV. a-b C57BL/6 mice were exposed for 4 weeks to FA or CS and instilled intranasal with Vehicle, (a) IAV or (b) RSV. Quantitative RT-PCR analysis for MMP-12 mRNA was performed at day 14 post viral infection. All samples were normalized to mouse GAPDH RNA levels. c-d Lung tissues from FA- or CS-exposed mice instilled intranasal with vehicle or (c) IAV or (d) RSV were analyzed for internucleosomal DNA fragmentation using TUNEL assay. N = 6 mice per group; data reported as mean ± SE; *p < 0.05; **p < 0.01, ***p < 0.001

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Respiratory Research

ISSN: 1465-993X

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