From: Advanced glycation endproducts and their receptor in different body compartments in COPD
 | Young healthy | Old healthy | COPD GOLD I-IV | Kruskal-Wallis |
---|---|---|---|---|
 | <40 years | >40 years | >40 years | p-value |
Plasma | n = 105 | n = 82 | n = 95 |  |
CEL, μg/ml | 10.2 (7.4-15.4) | 7.0 (4.8-10.6) ** | 6.8 (5.1-9.4) ** | 0.000* |
CML, μg/ml | 10.5 (0.0-29.5) | 9.2 (0.0-13.5) ** | 12.5 (0.0-21.6) **a | 0.042* |
Pentosidine, ng/ml | 36.8 (25.3-53.1) | 39.9 (30.1-52.0) | 46.1 (31.8-58.5) | 0.181 |
sRAGE, pg/ml | 795 (614-1089) | 805 (617-1032) | 414 (292-592) **a | 0.000* |
Induced sputum | n = 97 | n = 73 | n = 12 |  |
CEL, μg/ml | 5.9 (1.9-8.9) | 3.50 (0.0-6.9) | 6.0 (2.9-11.0) | 0.064 |
CML, μg/ml | 10.6 (0.0-22.7) | 10.4 (0.0-23.7) | 18.3 (11.2-22.5) | 0.409 |
Pentosidine, ng/ml | 0.0 (0.0-0.0) | 0.0 (0.0-0.0) | 0.0 (0.0-0.0) | 0.650 |
sRAGE, pg/ml | 78.1 (0.0-160.2) | 114.0 (0.0-240.5) | 110.9 (49.7-161.8) | 0.117 |
Bronchial Biopsies | n = 85 | n = 68 | n = 12 |  |
AGEs, positivity (%) | 31.1 (20.3-36.9) | 25.9 (20.9-35.4) | 25.5 (16.9-30.7) | 0.418 |
RAGE, positivity (%) | 9.8 (6.5-15.1) | 8.2 (5.7-11.8) | 8.0 (4.2-11.4) | 0.204 |
Skin | n = 107 | n = 83 | n = 96 |  |
AGE-reader, SAF | 1.2 (1.1-1.5) * | 1.8 (1.6-2.0) * | 2.5 (2.2-2.9) * | 0.000* |