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Fig. 3 | Respiratory Research

Fig. 3

From: Pirfenidone and nintedanib modulate properties of fibroblasts and myofibroblasts in idiopathic pulmonary fibrosis

Fig. 3

Transmission electron microscopy analysis of stromal cells derived from control lung (a, c, e, g) or IPF lung (b, d, f, h). Under normal cell culture conditions a, b there were only occasional myofibroblast features detected. TGFβ1 (5 ng/ml) c, d increased the myofibroblastic appearance such as the extracellular filament bundle (EFB), intracellular actin filament (a) and dilated rough endoplasmic reticulum (RER). Both 0.5 mM pirfenidone (e, f) and 0.5 μM nintedanib (g, h) reduced the numbers of TGFβ1 induced myofibroblastic features. Scale bar is 1 μm

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Respiratory Research

ISSN: 1465-993X

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