Fig. 7
From: Roflumilast partially reverses smoke-induced mucociliary dysfunction
Change in CFTR expression in brushed cells obtained during bronchoscopies and NHBE cultures. a Expression of CFTR is increased in brushed cells obtained from airways of smokers compared to non-smokers and ex-smokers. (four to six lungs, n = 12–18). b In cultured epithelial cells from non-smokers, acute exposure to cigarette smoke does not change CFTR expression compared to control air-exposed cells within 3 h of exposure. Roflumilast (red framed boxes) appears to increase CFTR expression in the smoke-exposed cells after 3 h (four lungs, n = 12) * for p < 0.05