Fig. 3
From: Roflumilast partially reverses smoke-induced mucociliary dysfunction
Effect of roflumilast on CFTR function. a Basolateral pretreatment of cells exposed to either air flow (air control; grey bars) or cigarette smoke (black bars) with 100 nM roflumilast improves CFTR function as measured by the decrease in Isc after apical application of 10 μM CFTRinh172; all cells were stimulated with 10 μM albuterol prior to CFTR inhibition. Roflumilast rescues CFTR function in smoke exposed cells to a level not different to the untreated air exposed cells. b Air and cigarette smoke exposed cultures show similar fold increases in CFTR conductance with and without roflumilast (19 lungs; n = 19). * p < 0.05