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Table 4 Exploratory analyses of total symptom scores, ANCOVA-adjusted means

From: Efficacy and safety of iota-carrageenan nasal spray versus placebo in early treatment of the common cold in adults: the ICICC trial

   

I-C vs. placebo

 

N

Adjusteda mean (SE)

Adjusteda mean (SE) differenceb

95 % CI

p-value*

TSS2–4, ex 1 pt

     

 I-C

97

5.67 (0.24)

−0.72 (0.34)

(−1.40, −0.05)

0.0364

 Placebo

97

6.39 (0.24)

   

TSS1-4

     

 I-C

98

6.02 (0.21)

−0.60 (0.30)

(−1.19, −0.00)

0.0495

 Placebo

97

6.62 (0.21)

   

TSS1–4, rel

     

 I-C

98

−0.08 (0.05)

−0.13 (0.06)

(−0.25, −0.01)

0.0421

 Placebo

97

0.05 (0.05)

   

Subset analyses

     

TSS2–4, virus positive patients

     

 I-C

53

5.87 (0.34)

−0.80 (0.48)

(−1.75, 0.15)

0.0986

 Placebo

54

6.67 (0.34)

   

TSS2–4, HRV/HEV positive patients

     

 I-C

27

6.08 (0.46)

−0.36 (0.65)

(−1.66, 0.94)

0.5820

 Placebo

28

6.44 (0.46)

   
  1. CI confidence interval
  2. *For ANCOVA-adjusted comparison of placebo with I-C
  3. aThe means were adjusted for baseline TSS
  4. bA negative treatment difference favours I-C