Predictors of diagnosis and survival in idiopathic pulmonary fibrosis and connective tissue disease-related usual interstitial pneumonia

Table 4 Clinical predictors of death in all UIP pathology

	Univariable HR (95% CI)	P value	Multivariable, HR (95% CI)	P value
Age at biopsy	1.04 (1.02-1.05)	<0.0001	1.03 (1.02-1.05)	<0.0001
Male gender	1.64 (1.29-2.11)	<0.001	1.55 (1.19-2.03)	0.0013
Smoking Hx	1.32 (1.04-1.69)	0.023	1.14 (0.88-1.49)	0.32
Duration of symptoms prior to biopsy	1.00 (0.99-1.01)	0.89	0.99 (0.99-1.00)	0.75
Positive autoimmune serology	0.72 (0.55-0.93)	0.02	0.83 (0.63-1.08)	0.18
GERD	0.96 (0.76-1.22)	0.75	0.94 (0.74-1.20)	0.64
FEV_1, % pred	0.98 (0.98-0.99)	<0.0001	0.99 (0.97-1.02)	0.64
FVC, % pred	0.98 (0.97-0.99)	<0.0001	0.99 (0.98-0.99)	0.003
DLCO, % pred	0.98 (0.98-0.99)	<0.0001	0.99 (0.98-0.99)	0.017
TLC, % pred	0.98 (0.97-0.99)	<0.0001	0.99 (0.98-1.02)	0.78
Initial HRCT pattern
Probable UIP	0.80 (0.59-1.09)	0.15	0.83 (0.61-1.13)	0.23
Probable NSIP or inconsistent with UIP	0.88 (0.64-1.22)	0.88	0.96 (0.70-1.33)	0.79
Atypical findings on biopsy	0.78 (0.56-1.07)	0.13	0.83 (0.59-1.14)	0.27

% pred = percent predicted.
Complete case analysis.
Multivariable adjustment for age, gender, smoking hx, FVC, and DLCO.
GERD = gastroesophageal reflux disease, NSIP = nonspecific interstitial pneumonia, UIP = usual interstitial pneumonia.

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