FEV | FVC | FEV or FVC | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Tiotropium | Placebo | Tiotropium | Placebo | Tiotropium | Placebo | |||||||
Time | N | Proportion | N | Proportion | N | Proportion | N | Proportion | N | Proportion | N | Proportion |
1 m | 2535 | 0.42 | 2416 | 0.55 | 2535 | 0.47 | 2416 | 0.62 | 2535 | 0.59 | 2416 | 0.73 |
6 m | 2515 | 0.42 | 2391 | 0.53 | 2515 | 0.44 | 2391 | 0.63 | 2515 | 0.57 | 2391 | 0.72 |
1 yr | 2503 | 0.39 | 2382 | 0.53 | 2503 | 0.43 | 2382 | 0.63 | 2503 | 0.55 | 2382 | 0.72 |
1.5 yr | 2380 | 0.40 | 2200 | 0.51 | 2380 | 0.43 | 2200 | 0.62 | 2380 | 0.56 | 2200 | 0.71 |
2 yr | 2236 | 0.39 | 2040 | 0.49 | 2236 | 0.43 | 2040 | 0.60 | 2236 | 0.56 | 2040 | 0.69 |
2.5 yr | 2132 | 0.39 | 1906 | 0.50 | 2132 | 0.42 | 1906 | 0.61 | 2132 | 0.55 | 1906 | 0.70 |
3 yr | 2012 | 0.36 | 1792 | 0.47 | 2012 | 0.39 | 1792 | 0.59 | 2012 | 0.52 | 1792 | 0.69 |
3.5 yr | 1894 | 0.36 | 1674 | 0.47 | 1894 | 0.41 | 1674 | 0.59 | 1894 | 0.52 | 1674 | 0.68 |
4 yr | 1804 | 0.35 | 1599 | 0.47 | 1804 | 0.39 | 1599 | 0.56 | 1804 | 0.51 | 1599 | 0.66 |
Estimated OR (95% CI) for change in proportion per year* | 0.92 (0.90, 0.94) | 0.91 (0.89, 0.94) | 0.93 (0.91, 0.95) | 0.94 (0.92, 0.96) | 0.92 (0.90, 0.94) | 0.92 (0.90, 0.95) | ||||||
p-value | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 |